Consequences of supplying methyl donors during pregnancy on the methylome of the offspring from lactating and non-lactating dairy cattle
نویسندگان
چکیده
The aim of this study was to evaluate the potential effects of methyl donor supplementation of pregnant animals in the presence or absence of a concomitant lactation on the methylome of the offspring. Twenty Holstein cows, 10 nulliparous (non-lactating while pregnant) and 10 multiparous (lactating while pregnant) were blocked by parity and randomly assigned to an i.m. weekly injections of a placebo (CTRL) or a solution containing methyl donors (MET). After calving, 5 calves randomly selected from each treatment (two born to non-lactating and three to lactating dams) were blood-sampled to determine their full methylome. There were more than 2,000 CpG differentially methylated between calves born to CTRL and those born to MET, and also between calves born to lactating and non-lactating dams. Most of the differences affected genes involved in immune function, cell growth regulation and differentiation, kinase activity, and ion channeling. We conclude that the coexistence of pregnancy and lactation affects the methylome of the offspring, and that supplementation of methyl donors early in gestation has also consequences on the methylome.
منابع مشابه
Enfluence of increasing dietary cation-anion balance on the performance of lactating dairy cattle
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Response of lactating dairy ruminant to different profiles of dietary calcium soaps of fatty acids
Nutrition has a significant effect on reproduction and lactation in Ruminant. Supply of require nutrient of dairy cows and ewes in early lactation is the main challenges that will be considered, since in most cases the animals facing negative energy balance after calving and the beginning of the period of lactation. Negative energy balance may sometimes result in reduced livestock production an...
متن کاملResponse of lactating dairy ruminant to different profiles of dietary calcium soaps of fatty acids
Nutrition has a significant effect on reproduction and lactation in Ruminant. Supply of require nutrient of dairy cows and ewes in early lactation is the main challenges that will be considered, since in most cases the animals facing negative energy balance after calving and the beginning of the period of lactation. Negative energy balance may sometimes result in reduced livestock production an...
متن کاملResponse of lactating dairy ruminant to different profiles of dietary calcium soaps of fatty acids
Nutrition has a significant effect on reproduction and lactation in Ruminant. Supply of require nutrient of dairy cows and ewes in early lactation is the main challenges that will be considered, since in most cases the animals facing negative energy balance after calving and the beginning of the period of lactation. Negative energy balance may sometimes result in reduced livestock production an...
متن کاملResponse of lactating dairy ruminant to different profiles of dietary calcium soaps of fatty acids
Nutrition has a significant effect on reproduction and lactation in Ruminant. Supply of require nutrient of dairy cows and ewes in early lactation is the main challenges that will be considered, since in most cases the animals facing negative energy balance after calving and the beginning of the period of lactation. Negative energy balance may sometimes result in reduced livestock production an...
متن کامل